Pudendal nerve injury reduces urethral outlet resistance in diabetic rats
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چکیده
منابع مشابه
Pudendal nerve injury reduces urethral outlet resistance in diabetic rats.
Diabetics have voiding and continence dysfunction to which elevated levels of advanced glycation end products (AGE) may contribute. In addition, pudendal nerve injury is correlated with voiding dysfunction and stress incontinence in rats. The aim of this study was to investigate whether pudendal nerve crush (PNC) in diabetic rats alters urinary function. Female virgin Sprague-Dawley rats (144) ...
متن کاملPudendal nerve stretch reduces external urethral sphincter activity in rats.
PURPOSE Most animal models of stress urinary incontinence simulate maternal injuries of childbirth since delivery is a major risk factor but they do not reproduce the nerve stretch known to occur during human childbirth. We hypothesized that pudendal nerve stretch produces reversible dysfunction of the external urethral sphincter. MATERIALS AND METHODS Female virgin Sprague-Dawley® rats were ...
متن کاملTime Course of Nerve Regeneration and Urethral Dysfunction after Bilateral Pudendal Nerve Injury in Female Rats
Aims of Study Stress urinary incontinence (SUI) is a significant medical problem affecting approximately 25 million Americans of all ages [1]. One of the epidemiologic factors most strongly associated with development of SUI in women is vaginal delivery of children [2], which can injure the nerves, muscles, and connective tissues responsible for maintaining continence [1]. In particular, the pu...
متن کاملExternal urethral sphincter activity in a rat model of pudendal nerve injury.
AIMS Pudendal nerve injury in the rat has been a useful animal model for studying stress urinary incontinence (SUI). However, the effect of pudendal nerve injury on activity of the external urethral sphincter (EUS) is relatively unexplored. The aims of this study were to examine voiding and the EUS electromyogram (EMG) in a durable SUI model in rats with bilateral or unilateral pudendal nerve t...
متن کاملPudendal nerve stimulation induces urethral contraction and relaxation.
In this study we measured urethral pressure changes in response to efferent pudendal nerve stimulation in rats. All other neural pathways to the urethra were transected, and the urethra was continuously perfused. We found fast twitch-like contractions, superimposed on a slow relaxation. The amplitude of the twitches was independent of the stimulation frequency below 26 Hz, whereas the relaxatio...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2010
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00341.2009